In November of 2019, the University of California Santa Cruz hosted a 3-day interdisciplinary conference to commemorate the 200th anniversary of the publication of Frankenstein, by Mary Shelley. A panel of senior researchers convened to discuss the impact of the novel on modern discussions of scientific ethics. The panel featured Nandini Bhattacharya, George Blumenthal, Michael M. Chemers, David Haussler, and Jenny Reardon. In the process, the panelists acted as the Institutional Review Board for a proposal from Victor Frankenstein himself.

Volume 19, Issue 5, May 2019, Page 24-26.

In diesem Buch werden Aspekte der Aussagenlogik und der Prädikaten­ logik der ersten Stufe behandelt. Eine Mathematisierung und Kalkü­ lisierung der Logik kann natürlich ganz verschieden ausfallen, je nach dem, von welchen Motiven man sich primär leiten läßt. Wir stellen drei Gesichtspunkte, die uns auch als die wesentlichsten erscheinen, in den Vordergrund: Die Formalisierung des Wahrheits­ begriffes, die Formalisierung des Beweisbarkeitsbegriffes und das Problem des Suchens nach Beweisen. Diese drei Aspekte führen zu drei verschiedenen Arten von Kalkülen. Die Betonung des (...) Wahrheitsbegriffes führte auf die untersuchung der Hilberttypkalküle von einem Standpunkt, wie er etwa auch im Buch von Rasiowa-Sikorski [Ra-Si] eingenommen wird. Hierbei wurde besonderen Wert auf die algebraischen Techniken gelegt, denn die Natur der Vollständigkeitsbeweise in diesen Kalkülen läßt sich u. E. eigentlich nur algebraisch verstehen. Etwas überspitzt könnte man formulieren, daß die Vollständigkeitsbeweise in Hilberttypkal­ külen Korollare zu Betrachtungen über Kongruenzrelationen in ge­ wissen Boole'schen Algebren sind. Bei den modelltheoretischen Be­ trachtungen haben wir uns kurz ge faßt und nur einige grundlegende Begriffe vorgestellt. (shrink)

This collection of essays by a group of international scholars focuses on specific issues in bioethics and paediatrics. It reflects interdisciplinary approaches to practical problems at the level of policy and practice.

Betrifft die Handschriften Codd. 12, 13 (S. 185), 134 (S. 181, 332, 336-337), 224 (S. 173), 325 (S. 246), 352 (S. 185), 540 (S. 113, 211) und A 91.8 (S. 2-3, 168, 177, 320, 328, 354) der Burgerbibliothek Bern.

The publication of DSM-5 has been accompanied by a fair amount of controversy. Amongst DSM’s most vocal ‘insider’ critics has been Thomas Insel, Director of the US National Institute of Mental Health. Insel has publicly criticised DSM’s adherence to a symptom-based classification of mental disorder, and used the weight of the NIMH to back a rival research strategy aimed at a more biology-based diagnostic classification. This strategy is part of Insel’s vision of a future, more preventative psychiatry in which mental (...) disorders are not only understood as biological disorders of the brain, but also as neurodevelopmental disorders. This paper examines the interest and merit of Insel’s views of mental and neurodevelopmental disorder for the philosophy of psychopathology, with a special focus of his neurodevelopmental model of schizophrenia. Pitman’s ‘moderate materialism’ will be used both as a philosophical lens through which to examine Insel’s position, as well as an example of a philosophical framework that may require updating and revision in the light of moves towards a neurodevelopmental conception of mental disorder. (shrink)

Genome Canada has funded a research project to evaluate the usefulness of different forms of ethical analysis for assessing the moral weight of public opinion in the governance of genomics. This paper will describe a role of public consultation for ethical analysis and a contribution of ethical analysis to public consultation and the governance of genomics/biotechnology. Public consultation increases the robustness of ethical analysis with a more diverse and rich accounts experiences. Consultation must be carefully and respectfully designed to generate (...) sufficiently diverse and rich accounts of moral experiences. Since dominant groupstend to define ethical or policy issues in a manner that excludes some interests or perspectives, it is important to identify the range of interests that diverse publics hold before defining the issue and scope of a consultation. Similarly, a heavy policy focus and pressures to commercialize products risk oversimplification of the discussion and the premature foreclosure of ethical dialogue. Consequently, a significant contribution of ethical dialogue strengthened by social analysis is to consider the context and non-policy use of power to govern genomics and to sustain social debate on enduring ethical issues. (shrink)

Physician assisted suicide or active euthanasia is analyzed as a medicalization of the needs of persons who are suffering interminably. As with other medicalized responses to personal needs, the availability of active euthanasia will likely divert attention and resources from difficult social and personal aspects of the needs of dying and suffering persons, continuing the pattern of privatization of the costs of caregiving for persons who are candidates for active euthanasia, limiting the ability of caregivers to assist suffering persons to (...) make their continued suffering tolerable, and casting doubt on the voluntariness of the choice of active euthanasia. Keywords: caregivers, euthanasia, family, medicalization, voluntariness CiteULike Connotea Del.icio.us What's this? (shrink)

In this article, I argue that Thomas Aquinas's primary intention in De Veritate 1.1 was to define truth rather than to offer a systematic doctrine of the transcendentals, and consider the implications of this reading for various aspects of Aquinas's philosophy and theology.

Why do people think that someone living a morally bad life is less happy than someone living a good life? One possibility is that judging whether someone is happy involves not only attributing positive psychological states (i.e., lots of pleasant emotions, few unpleasant emotions, and satisfaction with life) but also forming an evaluative judgment. Another possibility is that moral considerations affect happiness attributions because they tacitly influence attributions of positive psychological states. In two studies, we found strong support for the (...) second hypothesis. Moral considerations only appear to affect happiness attributions when they also affect attributions of positive psychological states. Additionally, both studies supported a hypothesis about why moral judgments have these effects. Specifically, we found that when people judge that someone is living a bad life, they infer that the person is not at peace with themselves. However, when this inference is blocked, moral considerations do not affect attributions of happiness or positive psychological states. In sum, although “happiness” appears to be a purely psychological concept, happiness judgments are sensitive to moral considerations because people often assume that immorality disrupts intrapersonal harmony. (shrink)

This paper examines the relationship between participation and motion with respect to the natural philosophy of the "Phaedo". Aristotle’s criticism of participation and its failure to account for motion shows the relevance of the dialogue to this problem. Challenging Aristotle’s critique, I interpret the "Phaedo" as offering a possible solution to the question of how forms cause motion in material beings. The verb ὀρέγεσθαι at 65c8, 75a2, and 75b1, together with the active ὀρέγειν at 117b2, ground an account of ontological (...) striving as a solution to the difficulties inherent in participation within the literary context of the dialogue. (shrink)

ABSTRACTThere is surprisingly little empirical evidence supporting theoretical and anecdotal claims regarding the spontaneous production of prototypic facial expressions used in numerous emotion re...

Now, in Emergent Forms of Life and the Anthropological Voice, path-breaking scholar Michael M. J. Fischer moves the discussion to a consideration of the ...

Many viral and cellular mRNA species contain a leader sequence derived from a distant upstream site on the same gene by a process of RNA splicing. This process usually involves either nuclear functions or self‐splicing of RNA molecules. Coronavirus, a cytoplasmic RNA virus, unfolds yet another mechanism of joining RNA, which involves the use of a free leader RNA molecule. This molecule is synthesized and dissociates from the template RNA, and subsequently reassociates with the template RNA at down‐stream initiation sites (...) of subgenomic mRNAs to serve as the primer for transcription. This leader‐primed transcriptional process thus generates viral mRNAs with a fused leader sequence. A similar mechanism might also operate in the mRNA transcription of African trypanosomes. (shrink)

This paper examines the divergent accounts of generation in Physics I and On Generation and Corruption. While the former concerns an unqualified and absolute generation of substance from not-substance, the latter describes the unqualified and simple generation of the elements from each other. In each of these texts, an unusual instance of ὀρέγεσθαι appears in Aristotle’s analysis, regarding the unqualified generation of substance at Phys. I 9, 192a18 and 19, and the cyclical transformation of the elements at GC II 10, (...) 336b28. These passages employ the verb consistently, suggesting that generation involves an ambiguous ontological desire. Such orectic striving differs greatly from human or other animal striving for some good. The accounts of generation in these texts are developed in order to emphasize both the distinction between the two processes and the significance of ontological desire to unqualified generation in its strongest sense. (shrink)

In Michael Stingl argues that the legalization of euthanasia can be made reasonable social policy only in the context of healthcare reform to deliver primary- and community-based care. Stingl accepts that euthanasia and that includes not only pain, but He is not worried The failure of the healthcare system to adequately respond to the needs of people who are suffering with chronic or terminal conditions may lead competent people to elect euthanasia. Stingl argues that it is the institutionalization of (...) care for dying people that reduces their ability to find meaning in prolonged life, and thereby makes it more attractive to consider ending one's life sooner. Options such as palliative care at home that significantly improve quality of life and make euthanasia less attractive are currently only available to those who can privately subsidize healthcare services. If an emphasis is placed on community-based initiatives and well-supported self-help, then there would be less inequality of healthcare and the voluntariness of choices, including euthanasia, would be more equal for all people under the healthcare system. (shrink)

Some decades before Umberto Eco refounded semiotics in the sixties, Alfred Schutz had already elaborated a theory on signs and symbols. Moreover, as Schutz himself affirms, neither was he the first to do so. The thoughts of Charles Sanders Peirce had already clearly influenced American pragmatism, and thinkers like George Herbert Mead and Ernst Cassirer had developed a theory of symbols, both referred to by Schutz in his later works. Nonetheless, sign theory was already present in his first book, Der (...) sinnhafte Aufbau der sozialen Welt, and can be traced to the influence of Edmund Husserl. Schutz’s focus on the analysis of the relationship between individual and society fomented his perception of the importance of intermediary communication and sign processes as the setting and interpretation of signs, “Zeichensetzung und Zeichendeutung”, reflections that in his later working phase resulted in a proper sign theory, which is analyzed in the following article. Based on Husserl’s concept of pairing, Schutz here develops his theory of appresentational references, comprising a subdivision of: marks, indications, signs and symbols. This involves the concept of representation, a relationship between the signifier and the signified, and a subjective as well as constructive interpretation by actors. Consequently, this concept involves an objective sign system, a social situation and, as inserted into a process of communication, complementary producers and receptors of signs and symbols. In the final comments the question is addressed whether, and in what sense, given the preceding theory of appresentational references, Schutz would hold that reality is a symbolic construction, as proposes the title of the 2016 conference on Schutz in Tokyo, The Symbolic Construction of Reality. (shrink)